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[Pyr1]-Apelin-13

CAS No. : 217082-60-5

MCE 站：[Pyr1]-Apelin-13

产品活性：[Pyr1]-Apelin-13 是一种选择性的内源性 apelin 受体激动剂。

研究领域：Others

作用靶点：Others

In Vitro: [Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained ａnd extended drug release under physiological conditions.

In Vivo: [Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity ａnd reduces pain symptoms, cavity size ａnd caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI.

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