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Rat CGRP-(8-37)

CAS No. : 129121-73-9

MCE 站：Rat CGRP-(8-37)

产品活性：Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) 是高度选择的 CGRP receptor 拮抗剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：CGRP Receptor

In Vitro: CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor.

In Vivo: CGRP-(8-37) is effective in alleviating mechanical ａnd thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb ａnd hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels.

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