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DTP3 TFA

CAS No. :

MCE 站：DTP3 TFA

产品活性：DTP3 TFA 是一种选择性的 GADD45β/MKK7 (生长停滞和 DNA 损伤诱导 β/促分裂原活化的蛋白激酶激酶 7) 抑制剂。DTP3 TFA 靶向 NF-κB 途径下游的一种重要的癌症选择性细胞存活模块。

研究领域：Cell Cycle/DNA Damage  |  MAPK/ERK Pathway

作用靶点：DNA/RNA Synthesis  |  JNK

In Vitro: DTP3 (10 μM; 1-21 days) causes the potent ａnd tumor-selective induction of JNK activation ａnd apoptosis, as shown by the appearance of phosphorylated JNK, as early as 24 hours.

In Vivo: DTP3 TFA (s.c.; 14.5 mg/kg/day; 28 days) has shown a dramatic shrinkage of the tumors, ａnd virtually eradicates established subcutaneous myeloma xenografts in mice.
DTP3 TFA (intravenous injection; 10 mg/kg/day) has t_1/2 of 1.26 hours, CL of 27.13 ML/min/kg, ａnd V_d of 2.80 L/kg.

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