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Glucagon-like peptide 1 (1-37), human TFA
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Glucagon-like peptide 1 (1-37), human TFA
CAS No. :
MCE 站：Glucagon-like peptide 1 (1-37), human TFA
产品活性：Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor.
研究领域：GPCR/G Protein
作用靶点：Glucagon Receptor
In Vitro: Glucagon-like peptide-1 (GLP-1) is produced by the posttranslational processing of proglucagon ａnd acts as a regulator of various homeostatic events. GLP-1(1-37) is more stable than GLP-1(7-37), with 94.7% of the initial amount of peptide left after a 4h exposure to mouse serum. GLP-1(1-37) is confirmed to be a highly potent agonist of the GLP-1 receptor (GLP-1R) by measuring the expression of the luciferase reporter gene expression in transiently transfected human embryonic kidney (HEK293) cells.
In Vivo: GLP-1(1–37) decreases glycemic excursion in a dose-dependent. The administration of GLP-1(1–37) or GLP-1(7–37) markedly decrease blood glucose levels at 15 min ａnd 30 min compared with the control group.
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