MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Chlorotoxin

CAS No. : 163515-35-3

MCE 站：Chlorotoxin

产品活性：Chlorotoxin是从雷蛇属以色列蝎子的毒液中提取的由36个氨基酸组成的肽段，具有抗癌活性。Chlorotoxin是氯离子通道 (chloride channel) 阻断剂。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Chloride Channel

In Vitro: Chlorotoxin (Chlorotoxin) preferentially binds to tumor cells ａnd has been harnessed to develop an imaging agent to help visualize tumors during surgical resection. In addition, chlorotoxin has potential as a vehicle to deliver anti-cancer drugs specifically to cancer cells. Chlorotoxin is shown to bind glioma cells, but is unable to bind normal rat astrocytes ａnd Te671, a human rhabdomyosarcoma cell line. Chlorotoxin inhibits the migration of U251MG (glioma) cells, with an IC₅₀ of 600 nM. Chlorotoxin binds to glioma cells is specific ａnd involves high affinity (K_d=4.2 nM) ａnd low affinity (K_d=660 nM) binding sites.Small conductance chloride channels are shown to be potently blocked by Chlorotoxin. Chlorotoxin has been used as a general pharmacological tool to investigate the function of chloride channels.

In Vivo: Chlorotoxin shows insecticidal activity on insects ａnd other invertebrates. After the administration of I-Chlorotoxin to tumor-bearing mice, the peptides accumulated within the tumor.Chlorotoxin selectively accumulates in the brain of tumor-bearing mice with calculated brain: muscle ratios of 36.4% of injected dose/g (ID/g), as compared to 12.4%ID/g in control animals.

相关产品：Shikonin  |  R(+)-IAA-94  |  DCPIB  |  NPPB  |  Selamectin  |  Adjudin  |  Endovion  |  Picrotoxinin  |  Niflumic acid  |  Flufenamic acid  |  Lubiprostone  |  T16Ainh-A01  |  Meticrane  |  Chlorotoxin TFA  |  NS1652  |  Spiperone hydrochloride  |  Talniflumate  |  Fenamic acid  |  Irisolidone  |  H100

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。