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GLP-2(3-33)

CAS No. : 275801-62-2

MCE 站：GLP-2(3-33)

产品活性：GLP-2(3-33) 由二肽基肽酶 IV (DPPIV) 产生，是一种 GLP-2 受体部分激动剂 (EC₅₀=5.8 nM)。

研究领域：GPCR/G Protein

作用靶点：Glucagon Receptor

In Vitro: GLP-2 is secreted as a 33-amino acid peptide, but is rapidly degraded at an N-terminus site to GLP-2(3-33) in circulation, in large part, by dipeptidylpeptidase IV (DPPIV). GLP-2 (3-33) acts as a partial agonist with potential competitive antagonistic properties on the GLP-2 receptor. In the GLP-2 receptor-binding assay, the binding IC₅₀ for GLP-2 1–33 was 3.1 nM, ａnd it was 41 nM for GLP-2 3-33. Thus, GLP-2 3–33 had 7.5% binding affinity compared to GLP-2 1-33.

In Vivo: GLP-2(3-33) (60 ng; once a day i.p. for 4 weeks) increases dyslipidemia ａnd hepatic lipid accumulation in HFD-fed mice.

相关产品：Exendin-4  |  Liraglutide  |  Glucagon (1-29), bovine, human, porcine  |  Avexitide  |  Adomeglivant  |  GLP-1(7-37)  |  GLP-1(7-36), amide acetate  |  BETP  |  GLP-2(1-33)(human)  |  GRA Ex-25  |  Cotadutide acetate  |  Glucagon-like peptide 1 (1-37), human TFA  |  NNC-0640  |  Taspoglutide  |  GLP-1 moiety from Dulaglutide  |  Glucagon receptor antagonists-2  |  Exendin-3/4 (59-86)  |  FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS  |  GLP-1(28-36)amide  |  GLP-1(32-36)amide  |  GLP-1(9-36)amide  |  Glucagon receptor antagonists-1  |  GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS  |  HAEGTFT  |  HAEGTFTSD

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