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WL47 TFA

CAS No. :

MCE 站：WL47 TFA

产品活性：WL47 TFA 是一种高亲和力的 cavolin-1 (CAV1) ligand (K_d=23 nM)，是一种有效的 CAV1 寡聚体破坏剂。WL47 TFA 对 CAV1 的选择性高于 BSA、酪蛋白和 HEWL。WL47 TFA 比原始 T20 (HY-P0052) 亲本序列长度小 80%，可用于 caveolin-1 功能的研究。

研究领域：Others

作用靶点：Others

In Vitro: Caveolin-1 (CAV) is a monotonic membrane protein, 22 kDa, it penetrates only one leaflet of the lipid bilayer, ａnd both the N- and C-termini remain on the cytoplasmic side. Multiple copies of CAV oligomerize can form high molecular weight complexes that bend the membrane inward to form invaginations, termed “caveolae,” of 50-100 nm in diameter.
T20 is a 36 amino acid peptide derived from gp41 ａnd blocks HIV viral fusion with CD4⁺ T-cells. WL47 is 80% smaller in length ａnd has 7500-fold greater affinity than the original T20 parent sequence.
In vitro, Demonstrating WL47 activity with CAV oligomers ａnd a method for measuring the degree of oligomerization. A variant of CAV (CAV(FLV)) that spontaneously oligomerizes to form CAV nanoparticles with diameters is used to examine deoligomerization by WL47. WL47 effectively disrupts these nanoparticles, but it does not disrupt oligomerization in the presence of a reducing agent, this demonstating that WL47 function requires dimerization by disulfide bond

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