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GLP-1(28-36)amide
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GLP-1(28-36)amide
CAS No. : 1225021-13-5
MCE 站:GLP-1(28-36)amide
产品活性:GLP-1(28-36)amide 是一段 GLP-1 的 C-端九肽,是一种中性内肽酶 (NEP) 裂解 GLP-1 的主要产物。GLP-1(28-36)amide 是一种抗氧化剂,靶向线粒体,抑制线粒体通透性转变 (MPT)。GLP-1(28-36)amide 具有抗糖尿病和心脏保护作用。
研究领域:GPCR/G Protein
作用靶点:Glucagon Receptor
In Vitro: Different from DPP-IV, NEP, which cleaves GLP-1(7-36)amide or GLP-1(9-36)amide to generate GLP-1(28-36)amide, is widely distributed in endothelial cells, vascular smooth muscle cells, cardiac cells and renal epithelial cells.
GLP-1(28-36)amide (100 nM) treatment on hepatocytes for 24 hours directly modulates mitochondrial oxidative metabolism, such as gluconeogenesis in mitochondria of hepatocytes.
The plasma half-life of GLP-1(28-36)amide is longer in human hepatocytes (t1/2 = 24 min) than that in mouse hepatocytes (t1/2 = 13 min).
In Vivo: The administration of GLP-1(28-36)amide at a rate of 18.5 nmol/kg BW/day for 9 weeks to diet-induced obese mice diminishes the development of hepatic steatosis.
The intraperitoneal injection of 18 nmol/kg GLP-1(28-36)amide once daily for 9 weeks show cytoprotective effect on pancreatic β cells by increasing mass and promoting proliferation in a β-cell injury diabetic mouse model.
An in vivo study in high-fat diet-fed mice indicates that a six-week administration of 18.5 nmol/kg GLP-1(28-36)amide improved hepatic glucose disposal, which is associated with increased cAMP levels and phosphorylation of PKA target.
Administered GLP-1(28-36)amide for 20 min to male C57BL6/J mice (10-12 week old), then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure (LVDP) is significantly greater in GLP-1(28-36)amide group compared to vehicle-treated hearts.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Diabetes Related Compound Library | Anti-Cardiovascular Disease Compound Library | Exendin-4 | Liraglutide | Glucagon (1-29), bovine, human, porcine | Avexitide | Adomeglivant | GLP-1(7-37) | GLP-1(7-36), amide acetate | BETP | GLP-2(1-33)(human) | GRA Ex-25 | Cotadutide acetate | Glucagon-like peptide 1 (1-37), human TFA | NNC-0640 | Taspoglutide | GLP-1 moiety from Dulaglutide | Glucagon receptor antagonists-2 | Exendin-3/4 (59-86) | FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | GLP-1(32-36)amide | GLP-1(9-36)amide | Glucagon receptor antagonists-1 | GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | HAEGTFT | HAEGTFTSD | HAEGTFTSDVS
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