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Alamandine

CAS No. : 1176306-10-7

MCE 站：Alamandine

产品活性：Alamandine 是一种血管活性肽，是肾素-血管紧张素系统 (RAS) 的成员，还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可通过抗高血压作用来保护肾脏和心脏。

研究领域：GPCR/G Protein  |  Metabolic Enzyme/Protease

作用靶点：Angiotensin Receptor  |  Angiotensin-converting Enzyme (ACE)

In Vitro: Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood.
Alamandine elevates cAMP concentration in primary endothelial ａnd mesangial cells, also suggesting Gs coupling.
Alamandine decreases secretion, expression, ａnd blood levels of leptin. Alamandine induced expression of iNOS ａnd plasminogen activator inhibitor-1 (PAI-1) in adipose tissue ａnd isolated adipocytes.

In Vivo: Alamandine (0.15  μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension ａnd impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart ａnd lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, ａnd inhibits the mRNA levels of atrial natriuretic peptide ａnd brain natriuretic peptide.

相关产品：Angiotensin II human  |  MLN-4760  |  Losartan  |  Captopril  |  Telmisartan  |  A 779  |  PD 123319 ditrifluoroacetate  |  AVE 0991  |  Valsartan  |  Enalapril maleate  |  Tranilast  |  Olmesartan  |  Diminazene aceturate  |  Irbesartan  |  YS-49  |  Lisinopril dihydrate  |  CGP-42112  |  Olodanrigan  |  Candesartan  |  Perindopril erbumine  |  Sparsentan  |  C-Type Natriuretic Peptide (CNP) (1-22), human  |  Fosinopril sodium  |  Sinapinic acid  |  Benazepril hydrochloride  |  Azilsartan medoxomil

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