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β-Amyloid (1-40) (TFA)

CAS No. :

MCE 站：β-Amyloid (1-40) (TFA)

产品活性：β-Amyloid (1-40) TFA 是阿尔茨海默症患者脑斑块中发现的一种主要蛋白片段。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vitro: β-Amyloid (1-40) ａnd (1-42) are major components of senile plaque amyloids, are physiological peptides present in the brain, cerebrospinal fluid (CSF) ａnd plasma. The levels of CSF β-Amyloid (1-40) ａnd (1-42) show a U-shaped natural course in normal aging.
The further aggregation of β-Amyloid (1-40)
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization ａnd randomization of structure.
2. The HFIP was removed by evaporation, ａnd the resulting peptide was stored as a film at -20 or -80°C.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM ａnd then diluted into the appropriate concentration ａnd buffer (serum- ａnd phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8°C. The sample was then centrifuged at 14000g for 10 min at 4-8°C; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.

相关产品：Deferoxamine mesylate  |  DAPT  |  β-Amyloid (25-35)  |  FPS-ZM1  |  Colivelin TFA  |  Rutin  |  β-Amyloid (1-42), human TFA  |  20(S)-Ginsenoside Rg3  |  Tolcapone  |  β-Amyloid (1-40)  |  Geniposide  |  Ginsenoside Rg1  |  β-Amyloid (1-42), rat TFA  |  Latrepirdine dihydrochloride  |  Licochalcone B  |  Semagacestat  |  Dihydroergocristine mesylate  |  Ginsenoside Re  |  β-Amyloid (42-1), human  |  Hematoxylin  |  Ginsenoside Rg2  |  Hoechst 34580 tetrahydrochloride  |  Notoginsenoside R1  |  Frentizole  |  Phenserine  |  LX2343  |  Scyllo-Inositol  |  Tramiprosate  |  Aftin-4

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