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Phosphatase Inhibitor Library

MCE 站：Phosphatase Inhibitor Library

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases ａnd kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation ａnd differentiation, metabolism, cell-cell interactions, etc. Protein phosphatases have evolved in separate families that are structurally ａnd mechanistically distinct. Based on substrate specificity ａnd functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases ａnd Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) ａnd PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action. MCE supplies a unique collection of 70 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) ａnd serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery ａnd related research.

Description & Advantages:

•   A unique collection of 70 phosphatase inhibitors for high throughput screening (HTS) ａnd high content screening (HCS).

•   The library contains compounds targeting protein tyrosine phosphatases (PTPs) ａnd serine/threonine-specific protein phosphatases (PP1, PP2A, ａnd PP2B, etc.).

•   Bioactivity ａnd safety confirmed by preclinical research ａnd clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, ａnd cell permeable.

•   Rich documentation with structure, IC₅₀, ａnd customer reviews.

•   NMR ａnd HPLC validated to ensure high purity.

•   All compounds are in stock ａnd continuously updated.

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