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Dupilumab

CAS No. : 1190264-60-8

MCE 站：Dupilumab

产品活性：Dupilumab (REGN-668) 是针对 IL-4 受体α (IL-4Rα) 的完全人类单克隆抗体，可抑制 IL-4 和 IL-13 信号转导，显着改善中度至重度特应性皮炎。

研究领域：Immunology/Inflammation

作用靶点：Interleukin Related

In Vitro: Dupilumab suppressed mRNA expressions of genes related to activation of T cells, DCs, eosinophils, inflammatory pathways, ａnd TH2-inducing chemokines in skin lesions. No significant reduction in IL-17A or IL-22 levels is detected, but large reductions in expression of IL-17–related genes, such as elafin (PI3), IL23p19/IL23A, ａnd S100A8 ａnd trends for suppression (CXCL1 ａnd S100A7) are found with 300 mg of Dupilumab.
Major suppressions of hyperplasia-related genes (eg, K16) ａnd reductions in expression of S100A genes are evident with 300 mg of Dupilumab by using microarrays ａnd qRT-PCR. The changes in other critical epidermal alterations in severe atopic dermatitis (AD) skin are also measured, including significant increases in claudin ａnd lipid product levels with 300 mg of Dupilumab. A trend of dose-dependent increases in expression of differentiation genes (LOR ａnd FLG) is observed after adjusting for suppression of epidermal hyperplasia, as demonstrated by K16 reductions with Dupilumab.

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