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ASK1-IN-1

CAS No. : 2411382-24-4

MCE 站：ASK1-IN-1

产品活性：ASK1-IN-1 是一种中枢神经系统渗透剂凋亡信号调节激酶 1 (ASK1) 抑制剂，具有良好的效价 (细胞 IC₅₀=138 nM; Biochemical IC₅₀=21 nM)。

研究领域：MAPK/ERK Pathway

作用靶点：p38 MAPK

In Vitro: ASK1-IN-1 (compound 21) has superior CYP inhibition profile ａnd it is also inactive in a hERG assay. ASK1-IN-1 is selected for a kinase selectivity profile against a panel of 468 kinases ａnd it is found to be moderately selective.

In Vivo: ASK1-IN-1 (10 mg/kg; p.o.) covers the cellular IC₅₀/IC₇₀/IC₉₀ at trough in the brain for 12 hours of 50/115/435 mg/kg respectively. ASK1-IN-1 has good biochemical ａnd cellular potency, low clearance ａnd good brain penetration in rodents.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  CNS-Penetrant Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  SB 203580  |  SB 202190  |  Doramapimod  |  Hesperetin  |  PD 169316  |  Neflamapimod  |  TAK-715  |  SB 239063  |  Dehydrocorydaline chloride  |  Talmapimod  |  PF-3644022  |  Bakuchiol  |  MAPK13-IN-1  |  Skatole  |  Semapimod tetrahydrochloride  |  Licochalcone E  |  SD 0006  |  ITX5061  |  p38α inhibitor 1  |  Rhoifolin  |  SKF-86002  |  C16-PAF  |  Dihydrocaffeic acid  |  Nitidine chloride  |  p38 MAPK-IN-1  |  Ferulic acid methyl ester  |  SD-169  |  Paris saponin VII

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