MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

GW3965 hydrochloride

CAS No. : 405911-17-3

MCE 站：GW3965 hydrochloride

产品活性：GW3965 hydrochloride 是肝 X 受体 (LXR) 激动剂，抑制 hLXRα 和 hLXRβ 的 EC₅₀ 分别为 190 nM 和 30 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：LXR

In Vitro: GW3965 hydrochloride promotes GBM cell death in vitro with enhanced efficacy in EGFRvIII-expressing tumor cells. GW3965 hydrochloride up-regulates expression of the cholesterol transporter gene ABCA1 ａnd the E3 ubiquitin ligase IDOL ａnd reduces LDLR levels. LXR ligands inhibits platelet aggregation ａnd calcium mobilization stimulated by collagen or CRP. GW3965 hydrochloride (1 or 5 μM) displays a minor inhibitory effect on fibrinogen binding ａnd P-selectin exposure, when platelets are stimulated with 1 μg/mL CRP. But using higher concentrations of GW3965 hydrochloride (10 μM) or T0901317 (40 μM), the levels of fibrinogen ａnd P-selectin on the platelet surface are reduced.

In Vivo: GW3965 hydrochloride induces an increase of neuroactive steroids in the spinal cord, the cerebellum ａnd the cerebral cortex of STZ-rats, but not in the CNS of non-pathological animals. GW3965 hydrochloride treatment induces an increase of dihydroprogesterone in the spinal cord of diabetic animals in association with an increase of myelin basic protein expression. GW3965 hydrochloride (40 mg/kg, p.o.) strongly induces ABCA1 expression ａnd reduces LDLR expression, ａnd this is accompanied by 59% inhibition of tumor growth, ａnd a 25-fold increase in GBM cell apoptosis in vivo. GW3965 hydrochloride (2 mg/kg, i.v.) increases bleeding time ａnd modulated platelet thrombus formation in vivo.

相关产品：Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Diabetes Related Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  T0901317  |  GSK2033  |  LXR-623  |  27-Hydroxycholesterol  |  (20S)-Protopanaxatriol  |  SR9243  |  SR9238  |  24-Hydroxycholesterol  |  AZ876  |  Saikosaponin A  |  Yamogenin  |  Nagilactone B  |  DMHCA  |  Gymnestrogenin  |  Iristectorigenin B  |  LXRβ agonist-2

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。