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Autophagy Compound Library

MCE 站：Autophagy Compound Library

Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.MCE provides a unique collection of 1076 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Description & Advantages:

?   A unique collection of 1076 small molecule compounds with biological activity used for autophagy research and associated assays.

?   Targets include Autophagy, LRRK2, and ULK.

?   A useful tool for the research of autophagy-related regulation and diseases.

?   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

?   Structurally diverse, medicinally active, and cell permeable.

?   Detailed compound information with structure, IC₅₀, and brief introduction.

?   Validated NMR and HPLC to ensure high purity and quality.

?   All compounds are in stock and continuously updated.

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