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Endoplasmic Reticulum Stress Compound Library

MCE 站：Endoplasmic Reticulum Stress Compound Library

Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer.MCE Endoplasmic Reticulum Stress Compound Library contains 187 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.

Description & Advantages:

?   A unique collection of 187 ER stress-related small molecules for high throughput screening (HTS) and high content screening (HCS).

?   Targets such as PERK, IRE1, ATF6, etc.

?   A useful tool for drug discovery of ER stress-related diseases.

?   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

?   Structurally diverse, medicinally active, and cell permeable.

?   More detailed compound information with structure, IC₅₀, and brief introduction.

?   NMR and HPLC validated to ensure high purity and quality.

?   All compounds are in stock and continuously updated.

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