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MAPK Compound Library
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MAPK Compound Library
MCE 站:MAPK Compound Library
MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.MCE designs a unique collection of 263 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.
Description & Advantages:
? A unique collection of 263 MAPK signaling inhibitors for high throughput screening (HTS) and high content screening (HCS).
? Targets such as ERK, JNK, MEK, p38 MAPK, Raf, RSK, etc.
? A useful tool for MAPK-related drug discovery and disease research.
? Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
? Structurally diverse, medicinally active, and cell permeable.
? More detailed compound information with structure, IC50, and brief introduction.
? NMR and HPLC validated to ensure high purity and quality.
? All compounds are in stock and continuously updated.
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