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Neurotransmitter Receptor Compound Library
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Neurotransmitter Receptor Compound Library
MCE 站:Neurotransmitter Receptor Compound Library
Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding.In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy.MCE designs a unique collection of 1099 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.
Description & Advantages:
? A unique collection of 1099 small molecule modulators used for neurological diseases research.
? The library contains compounds targeting neurotransmitter receptors including mAChR, nAChR, Adrenergic Receptor, Dopamine Receptor, etc.
? A useful tool for neurological diseases drug discovery.
? Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
? Structurally diverse, medicinally active, and cell permeable.
? Rich documentation with structure, IC50, and summary.
? NMR and HPLC validated to ensure high purity.
? All compounds are in stock and continuously updated.
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