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Protein Tyrosine Kinase Compound Library

MCE 站：Protein Tyrosine Kinase Compound Library

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.MCE designs a unique collection of 597 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Description & Advantages:

?   A unique collection of 597 protein kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).

?   Targets such as VEGFR, ALK, Btk, Bcr-Abl, c-Met/HGFR, EGFR, FGFR, Insulin Receptor, JAK, PDGFR, etc.

?   A useful tool for the research for PTK-related diseases, such as cancer.

?   Bioactivity and safety confirmed by preclinical research and clinical trials. Some protein kinase inhibitors have been approved by FDA.

?   Structurally diverse, medicinally active and cell permeable.

?   Rich documentation with structure, IC₅₀ and summary.

?   NMR and HPLC to ensure the high purity.

?   All compounds are in stock and continuously updated.

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