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Pyroptosis Compound Library

MCE 站：Pyroptosis Compound Library

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.MCE designs a unique collection of 714 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signal pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Description & Advantages:

?   A unique collection of 714 small molecules used for pyroptosis research.

?   Targets such as Caspase-1, Caspase-4, Caspase-5, gasdermin D, NLRP3 , etc.

?   Bioactivity and safety confirmed by preclinical research and clinical trials, some compounds have been approved by FDA.

?   A useful tool to study pyroptosis-involved regulation and diseases such as cancer, cardiovascular diseases and Metabolic disorder, etc.

?   Structurally diverse, medicinally active, and cell permeable.

?   More detailed compound information with structure, IC₅₀, and other chemical & biological data.

?   NMR and HPLC validated to ensure high purity and quality.

?   All compounds are in stock and continuously updated.

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