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Reprogramming Compound Library

MCE 站：Reprogramming Compound Library

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.MCE Reprogramming Compound Library contains a unique collection of 1242 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Description & Advantages:

?   A unique collection of 1242 reprogramming compounds for high throughput screening (HTS) and high content screening (HCS).

?   Epigenetic modifiers, metabolism regulators, cell senescence alleviators and signaling pathway modulators such as Wnt activators, MET activators, Hedgehog activators are included.

?   A useful tool for the research of reprogramming.

?   More detailed compound information with structure, IC₅₀, and other chemical & biological data.

?   NMR and HPLC validated ensure high purity.

?   All compounds are in stock and continuously updated.

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•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
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