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TGF-beta/Smad Compound Library

MCE 站：TGF-beta/Smad Compound Library

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.MCE designs a unique collection of 127 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

Description & Advantages:

?   A unique collection of 127 TGF-beta/Smad inhibitors for high throughput screening (HTS) and high content screening (HCS).

?   Targets include PKC, ROCK, TGF-beta/Smad, and TGF-β Receptor.

?   A useful tool for researching TGF-beta/Smad-related regulation and diseases.

?   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

?   Structurally diverse, medicinally active, and cell permeable.

?   More detailed compound information with structure, IC₅₀, and brief introduction.

?   NMR and HPLC validated to ensure high purity and quality.

?   All compounds are in stock and continuously updated.

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