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Ruxolitinib phosphate

CAS No. : 1092939-17-7

MCE 站：Ruxolitinib phosphate

产品活性：Ruxolitinib phosphate (INCB018424 phosphate) 是一种有效的 JAK1/2 抑制剂， IC₅₀ 分别为3.3 nM/2.8 nM，比JAK3选择性高130倍。

研究领域：Epigenetics  |  Stem Cell/Wnt  |  JAK/STAT Signaling  |  Autophagy

作用靶点：JAK  |  Autophagy  |  Mitophagy

In Vitro: Ruxolitinib (INCB018424) potently and selectively inhibits JAK2V617F-mediated signaling and proliferation. Ruxolitinib inhibits the growth of HEL cells with EC₅₀ of 186 nM. Ruxolitinib markedly increases apoptosis in Ba/F3-EpoR-JAK2V617F cell system, and inhibits hematopoietic progenitor cell proliferation in primary MPN patient samples.

In Vivo: Ruxolitinib (180 mg/kg, p.o.) reduces the tumor burden of mice inoculated with JAK2V617F-expressing cells without causing anemia or lymphopenia.

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