MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Vinpocetine

CAS No. : 42971-09-5

MCE 站：Vinpocetine

产品活性：Vinpocetine (Ethyl apovincaminate) 是一种长春花生物碱衍生物，可阻断 Na⁺ 通道。Vinpocetine 抑制 IKK 的 IC₅₀ 值为 17.17 μM。Vinpocetine 还是 PDE 抑制剂，并通过直接靶向 IKK 抑制 NF-κB 依赖性炎症反应，已被广泛用于研究脑血管疾病。

研究领域：Membrane Transporter/Ion Channel  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Sodium Channel  |  IKK  |  Phosphodiesterase (PDE)

In Vitro: Vinpocetine (5-50 μM; 7 hours; VSMCs, HUVECs, A549 cells and RAW264.7 cells) potently inhibits TNF-α-induced NF-κB-dependent transcriptional activity in a dose-dependent manner with an approximate IC₅₀ value of 25 μM. Vinpocetine do not have a significant effect on cell viability.
Vinpocetine (50 μM; 7 hours; VSMCs, HUVECs, A549 cells and RAW264.7 cells) potently inhibits TNF-α-induced up-regulation of TNF-α, IL-1β, IL-8, MCP-1, VCAM-1, ICAM-1and MIP-2 transcripts in several cell types.

In Vivo: Vinpocetine (2.5-10 mg/kg; intraperitoneal injection; C57BL/6 mice) potently inhibits TNF-α- or LPS-induced up-regulation of proinflammatory mediators, including TNF-α, IL-1β, and MIP-2, and decreases interstitial infiltration of polymorphonuclear leukocytes in a mouse model of TNF-α- or LPS-induced lung inflammation.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Membrane Transporter/Ion Channel Compound Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Differentiation Inducing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  NMPA-Approved Drug Library  |  Pyroptosis Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Alzheimer’s Disease Compound Library  |  Neuroprotective Compound Library  |  Alkaloids Library  |  BAY 11-7082  |  IBMX  |  Resveratrol  |  Bucladesine sodium  |  BX795  |  EIPA  |  Amiloride hydrochloride  |  Amlexanox  |  Monensin sodium salt  |  TPCA-1  |  Rolipram  |  Sildenafil  |  Carbamazepine  |  MRT67307  |  IMD-0354  |  5-(N,N-Hexamethylene)-amiloride  |  Riluzole  |  Theophylline  |  Icariin  |  Roflumilast  |  Tadalafil  |  PF-04957325  |  Milri  |  Dipyridamole  |  20(S)-Ginsenoside Rg3  |  Lidocaine  |  Amitriptyline hydrochloride  |  Cariporide

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。