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Exendin-4
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Exendin-4
CAS No. : 141758-74-9
MCE 站:Exendin-4
产品活性:Exendin-4 (Exenatide) 是由 39 个氨基酸组成的多肽。它是长效的 glucagon-like peptide-1 受体激动剂,IC50 值为 3.22 nM。
研究领域:GPCR/G Protein
作用靶点:Glucagon Receptor
In Vitro: In human umbilical vein endothelial cells, exendin-4 significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner. Exendin-4 shows cytotoxic effects to MCF-7 breast cancer cells with IC50 of 5 μM at 48 hour.
In Vivo: Both low- and high-dose exendin-4 treatment in ob/ob mice improve serum ALT and reduce serum glucose, and calculated HOMA scores compared with control. Exendin-4-treated ob/ob mice sustain a marked reduction in the net weight gain in the final 4 weeks of the study period. Animals treated with exendin-4 have more pancreatic acinar inflammation, more pyknotic nuclei and weigh significantly less than control rats. Exendin-4 treatment is associated with lower leptin levels as well as lower HOMA values in rats. Exenatide causes dose-dependent relaxation of rat thoracic aorta, which is evoked via the GLP-1 receptor and is mediated mainly by H2S but also by NO and CO.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Diabetes Related Compound Library | Anti-Breast Cancer Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Liraglutide | Glucagon (1-29), bovine, human, porcine | Avexitide | Adomeglivant | GLP-1(7-37) | GLP-1(7-36), amide acetate | Exendin-4 acetate | BETP | GLP-2(1-33)(human) | GRA Ex-25 | NNC-0640 | Cotadutide acetate | Glucagon-like peptide 1 (1-37), human TFA | Taspoglutide | GLP-1 moiety from Dulaglutide | Glucagon receptor antagonists-3 | GLP-1(9-36)amide | GLP-2(3-33) | Exendin-3/4 (59-86) | FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | GLP-1(28-36)amide | GLP-1(32-36)amide | GLP-1R Antagonist 1 | Glucagon receptor antagonists-1 | GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | HAEGTFT
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