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Betulinic acid

CAS No. : 472-15-1

MCE 站：Betulinic acid

产品活性：Betulinic acid 是一种天然的五环三萜类化合物，为真核细胞拓扑异构酶 I (topoisomerase I) 的抑制剂，IC₅₀ 值为 5 μM，具有抗炎，抗疟疾，抗艾滋病和抗肿瘤等活性。Betulinic acid 也是一种新的 NF-kB 的激动剂。

研究领域：Apoptosis  |  Cell Cycle/DNA Damage  |  Anti-infection  |  Autophagy  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Topoisomerase  |  HIV  |  Autophagy  |  Mitophagy  |  NF-κB  |  Endogenous Metabolite

In Vitro: Betulinic acid is a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and prevents topoisomerase I-DNA interaction. Betulinic acid (10, 20, 40, 80, and 160 ?M) significantly suppresses MDA-MB-231 cell viability in a time- and dose-dependent manner after treatment for 24 or 48 h. Betulinic acid (20, 40 ?M) causes decrease in Bcl-2 expression of MDA-MB-231 cells. Betulinic acid also induces morphological changes of MDA-MB-231 cells at 20 ?M, and leads to ultrastructure changes of MDA-MB-231 cells at 40 ?M. Betulinic acid shows anti-HIV activities, with an EC₅₀ of 1.4 ?M in acutely infected H9 lymphocytes.

In Vivo: Betulinic acid (10 and 30 mg/kg, p.o.) significantly abrogates colon shortening, and reduces malondialdehyde (MDA) and lipid hydroperoxide levels in dextran sulfate sodium (DSS)-induced colitis in mice. Betulinic acid (30 mg/kg, p.o.) restores superoxide dismutase (SOD), catalase activity and glutathione (GSH) content to control levels in DSS-induced colitis in mice. Betulinic acid (30 mg/kg, p.o.) also inhibits the DSS-induced increase in inflammatory markers. Betulinic acid (3, 10, 30 mg/kg, p.o.) suppresses acetic acid-induced writhing responses and mustard oil (MO)-induced visceral nociception in mice.

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