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Nystatin

CAS No. : 1400-61-9

MCE 站：Nystatin

产品活性：Nystatin 是一种口服有效的多烯类抗真菌抗生素 (antifungal antibiotic)，对酵母和支原体有效。Nystatin 可增加质膜对包括氯离子等小单价离子的通透性。Nystatin 是一种胆固醇隔离试剂，可部分阻止 Oxaliplatin 诱导的脂筏聚集、DR4 和 DR5 聚集，从而减少细胞凋亡。

研究领域：Anti-infection  |  Apoptosis

作用靶点：Fungal  |  Antibiotic  |  Apoptosis

In Vitro: Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six?Candida?species.?Nystatin is an antibiotic that increases the permeability of plasma membranes to small monovalent ions, including chloridion. Nystatin increases apical chloridion permeability to the point where transepithelial chloridion transport is limited by transport across the basolateral membrane of tracheal epithelial cells, which reflects primarily the activity of the cotransporter. Nystatin (400 units/mL) increases the basal level of transepithelial 36Cl flux approximately 1.5-fold and eliminates UTP stimulation of this flux. Nystatin treatment also abolishes UTP stimulation of saturable, basolateral [³H]bumetanide binding, a measure of functioning Na-K-Cl cotransporters in these cells; isoproterenol stimulation of binding is only mildly inhibited by nystatin treatment.?Nystatin significantly enhances endostatin uptake by endothelial cells through switching endostatin internalization predominantly to the clathrin-mediated pathway. Nystatin-enhanced internalization of?endostatin also increases its inhibitory effects on endothelial cell tube formation and migration.

In Vivo: Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo.?Liposomal?Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group.

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