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Kinetin

CAS No. : 525-79-1

MCE 站：Kinetin

产品活性：Kinetin (N6-furfuryladenine) 属于 N6-取代腺嘌呤衍生物细胞分裂素家族，细胞分裂素是参与细胞分裂、分化等生理过程的植物生长激素。Kinetin 具有抗衰老作用。

研究领域：Others

作用靶点：Others

In Vitro: Kinetin (N6-furfuryladenine) shows to have a direct effect on superoxide dismutase activity in plants; prevent oxidation of unsaturated acids in plant membranes; slow down development and aging in insects, by reducing their fecundity and increasing the specific activity of catalase; and delay the onset of many age-related characteristics that appear in normal human skin fibroblasts undergoing aging in vitro. Kinetin (70-150 μM) markedly suppressed hydroxyl radical formation by about 41% and 76%, respectively.
The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured familial dysautonomia (FD) cells.

In Vivo: Kinetin (N6-furfuryladenine) (2-6 mg/kg; injection into the tail vein) effectively prevents ADP-induced acute pulmonary thrombosis in mice.
Subjects received 23.5 mg/kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant.

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