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Solasodine

CAS No. : 126-17-0

MCE 站：Solasodine

产品活性：Solasodine (Purapuridine) 是类固醇生物碱，存在于茄科植物中。Solasodine 具有神经保护，抗真菌，降压，抗癌，抗动脉粥样硬化，抗雄激素和抗炎活性。

研究领域：Apoptosis  |  Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：MDM-2/p53  |  Fungal  |  E1/E2/E3 Enzyme  |  Apoptosis

In Vitro: Solasodine (90 μM; 2 days) treatment displays significant sprouting in P19 cells. Solasodine induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine induces the differentiation of P19 cells, essentially towards the neuronal pathway.Solasodine induce apoptosis by inhibiting the p53-MDM2 complex, p21^Waf1/Cip1, and Bcl-2 proteins.

In Vivo: Solasodine (25-100?mg/kg; intraperitoneal injection; once) treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine has anticonvulsant and CNS depressant activities.
Solasodine (375 μM; i.c.v.; for 2 weeks) treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells.

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