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Honokiol
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Honokiol
CAS No. : 35354-74-6
MCE 站:Honokiol
产品活性:Honokiol是一种具有生物活性的双酚类植物化学物质,靶向多种信号分子,具有有效的抗氧化,抗炎,抗血管生成和抗癌活性。 它抑制 Akt 的活化并增强 ERK1/ERK2 的磷酸化。Honokiol 能透过血脑屏障。
研究领域:PI3K/Akt/mTOR | Stem Cell/Wnt | MAPK/ERK Pathway | Autophagy | Anti-infection
作用靶点:Akt | ERK | Autophagy | HCV
In Vitro: Honokiol (0, 12.5, 25 and 50 μM) inhibits the growth of GBM cells and induces apoptosis, with IC50 of appr against 30 μM DBTRG-05MG cell. Honokiol-induced apoptosis of GBM cells is associated with the downregulation of the Rb protein and cleavage of PARP and Bcl-x (S/L). Honokiol (50 μM) increases the level of autophagy markers in GBM cells. Honokiol has anticancer effect, and the IC50 values with MDA-MB-231, MDA-MB-468, and MDA-MB-453 cell lines is 16.99 ± 1.28 μM, 15.94 ± 2.35 μM and 20.11 ±3.13 μM respectively. Honokiol (3, 10 μM) produces significant inhibition on the spheroid number and spheroid sizes in the clonogenic assay. Honokiol (0.1-1.0?μM) specifically inhibits washed human platelet aggregation stimulated by collagen, but not by other agonists. honokiol (0.6 and 1.0?μM) can concentration-dependently inhibit the collagen-induced ATP-release reaction in washed human platelets. Honokiol specifically inhibits platelet aggregation and the phosphorylation of Lyn, PLCγ2, and PKC stimulated with convulxin. Honokiol (5, 10?μM) significantly inhibits convulxin-stimulated MAPKs and Akt activation. Honokiol (10, 20 μM) increases ERK1/2 phosphorylation in a dose-dependent manner depending on CaMK II activation.
In Vivo: Honokiol-NM (40 mg/kg, p.o.) produces superior anticancer effects, and the PCNA, Cyclin D1 and cleaved caspase 3 expressions are 2.12, 1.92 and 1.68-fold significantly altered in this treated group.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Antiviral Compound Library | CNS-Penetrant Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Endoplasmic Reticulum Stress Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Monomer Library | FDA Approved & Pharmacopeial Drug Library | Neuroprotective Compound Library | Anti-Hepatitis C Virus Compound Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | PD98059 | Resiquimod | TBHQ | Tauroursodeoxycholate Sodium | Ribavirin | Ravoxertinib | Deferiprone | GSK-690693 | U18666A | AG-1478 | EIDD-1931 | Astragaloside IV | Artemisinin | Piperlongumine | Oridonin | Perifosine | Guggulsterone | Miransertib | NIM811 | BIX02189 | Triciribine | Recilisib | SU6656 | Alisporivir | Isobavachalcone | Myriocin | Scutellarin | FR 180204
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