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Etoposide

CAS No. : 33419-42-0

MCE 站：Etoposide

产品活性：Etoposide (VP-16; VP-16-213) 是一种常用的抗肿瘤化疗剂。Etoposide 抑制拓扑异构酶 II (topoisomerase-II)，从而抑制 DNA 复制。Etoposide 诱导细胞周期停滞，凋亡 (apoptosis) 和自噬 (autophagy)。

研究领域：Cell Cycle/DNA Damage  |  Autophagy  |  Anti-infection  |  Apoptosis

作用靶点：Topoisomerase  |  Autophagy  |  Mitophagy  |  Bacterial  |  Apoptosis  |  Antibiotic

In Vitro: Etoposide is capable of causing cytotoxicity on pancreatic β-cells by inducing apoptosis through the JNK/ERK-mediated GSK-3 downstream-triggered mitochondria-dependent signaling pathway in RIN-m5F cells.
Etoposide and Anti-Human VEGF significantly abolish P1 sphere-forming ability, an effect associated with apoptosis of this subset of cells.
Etoposide phosphate (0-1μM; 72 hours) inhibits HCT116 FBXW^+/+, FBXW^-/- and p53^-/- as a dose-dependent manner, exhibits IC₅₀s of 0.945 μM; 0.375 μM; and 1.437 μM, respectively.
Etoposide (25 μM; 6 hours) delays p53 recover in FBXW7-deficient cells. In addition, FBXW7 expression is disappeared in FBXW7^-/- cells.

In Vivo: Etoposide (50 μM) and Anti-Human VEGF-treated hypoxic cells injected intravenously into immunodeficient mice reveals a reduced capacity to induce lung colonies, which also appear with a longer latency period. Etoposide (10 mg/kg/day, i.v.) with NSC 109724 and NSC 241240, reduces the tumor volume in the hepatoblastoma cell injected NMRI nude mice.

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