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Natamycin

CAS No. : 7681-93-8

MCE 站：Natamycin

产品活性：Natamycin (Pimaricin) 是由数个链霉菌菌株生产的大环内酯类抗生素，可通过抑制氨基酸和葡萄糖跨质膜的运输来抑制真菌的生长。Natamycin (Pimaricin) 是一种食品防腐剂，在农业中是一种抗真菌剂，被广泛用于真菌性角膜炎的研究。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Fungal  |  Endogenous Metabolite  |  Antibiotic

In Vitro: Natamycin, an important macrolide antibiotic, produced by several Streptomyces species, including S. natalensis, S. gilvosporeus, S. lydicus and S. chattanoogensis, can inhibit the growth of fungi via immediate inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is widely used in the food industry and in pharmacotherapy for topical treatment. Unlike other polyene antibiotics, the mode of action of Natamycin is not based on the ergosterol-dependent permeabilization of the plasma membrane. The immediate cessation of growth of yeasts by Natamycin treatment indicates that there might be an instantaneous effect of Natamycin at the level of the plasma membrane.

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