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Dihydrocoumarin

CAS No. : 119-84-6

MCE 站：Dihydrocoumarin

产品活性：Dihydrocoumarin 是在 Melilotus officinalis 中发现的一种化合物。Dihydrocoumarin 是酵母 Sir2p 抑制剂。 Dihydrocoumarin 还抑制人 SIRT1 和 SIRT2，IC ₅₀ 分别为 208 μM 和 295 μM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：Sirtuin

In Vitro: Dihydrocoumarin induces a concentration-dependent inhibition of SIRT1 (IC₅₀ of 208 μM) in an in vitro enzymatic assay. A decrease in SIRT1 deacetylase activity is observed even at micromolar doses (85±5.8 and 73±13.7% activity at 1.6 μM and 8 μM, respectively). The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC₅₀ of 295 μM).
Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. A 5-mM dose of Dihydrocoumarin increases apoptosis at the 6-h time point in the TK6 cell line.
Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period.

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