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Triphala

CAS No. : 857906-76-4

MCE 站：Triphala

产品活性：Triphala 是阿育吠陀的多草药配方，Triphala 由三种草本植物 Terminalia chebula，Terminalia bellerica，和 Phyllanthus emblica 组成。Triphala 抑制 NF-κB 活化。Triphala 发挥抗真菌 (antifungal) 作用。具有抗脂肪形成，抗炎，抗肿瘤效果。

研究领域：NF-κB  |  Anti-infection

作用靶点：NF-κB  |  Fungal

In Vitro: Triphala regulates adipogenesis through modulation of expression of adipogenic genes in 3T3-L1 cell line. Triphala significantly decreases the adipogenesis in 3T3-L1 cells by reducing lipid accumulation and inhibiting the expression of adipogenic genes. The 3T3-L1 cells treated with Triphala show ~1.43-, 1.67-, and 2.5-fold decreases in lipid content at 1, 10, and 100 μg/mL concentrations, respectively, compared to the cells treated with induction cocktail alone. Triphala regulates lipid accumulation by down regulating expression of adipogenic genes, resulting into prevention of adipogenesis.
Triphala reduces expression of inflammatory mediators such as IL-17, COX-2, and RANKL through inhibition of NF-κB activation. Triphala exerts antifungal action against Asperigillus species and has been reported to inhibit the fungus by up to 37.96% in vitro.

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