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Sinapinic acid
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Sinapinic acid
CAS No. : 530-59-6
MCE 站:Sinapinic acid
产品活性:Sinapinic acid (Sinapic acid) 是从 Hydnophytum formicarum Jack. 根中分离到的酚类化合物,为 HDAC 的抑制剂,IC50 值 2.27 mM,对 ACE-I 的活性也有抑制作用。Sinapinic acid 具有有效的抗肿瘤活性,诱导肿瘤细胞凋亡。Sinapinic acid 具有抗氧化、抗糖尿病的作用。Sinapinic acid 可以降低卵巢切除大鼠的总胆固醇、甘油三酯和 HOMA-IR 指数,并使抗氧化能力和氧化损伤的一些血清参数正常化。
研究领域:Cell Cycle/DNA Damage | Epigenetics | Metabolic Enzyme/Protease | NF-κB | Immunology/Inflammation | Apoptosis
作用靶点:HDAC | Angiotensin-converting Enzyme (ACE) | Reactive Oxygen Species | Apoptosis
In Vitro: Sinapinic acid acts as an inhibitor of HDAC, with an IC50 of 2.27 mM. Sinapinic acid also inhibits ACE-I activity.
Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC50s of 0.91 ± 0.02 mM and 1.6?±?0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells.
In Vivo: Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Reprogramming Compound Library | Diabetes Related Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Medicine Food Homology Compound Library | Phenols Library | Pyroptosis Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | MG-132 | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | Acetylcysteine | Angiotensin II human | SP600125 | 5-Fluorouracil | Staurosporine | Bortezomib | H2DCFDA | Tamoxifen | 2-Deoxy-D-glucose | Gemcitabine | Trichostatin A | Verteporfin | Decitabine | Actinomycin D | Temozolomide | BAY 11-7082 | Etoposide | Mitomycin C | CCCP | DAPT | Rote | Etomoxir | Stattic
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