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(Arg)9 TFA
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(Arg)9 TFA
CAS No. : 2283335-13-5
MCE 站:(Arg)9 TFA
产品活性:(Arg)9 TFA (Nona-L-arginine TFA)是可渗透细胞的多肽,在谷氨酸模型实验模型中保护神经的IC50值为0.78 μM。
研究领域:Others
作用靶点:Others
In Vitro: Poly-arginine (e.g. (Arg)9) and arginine-rich peptides (e.g. TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. (Arg)9 provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC50=6 μM).
In Vivo: (Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after permanent middle cerebral artery occlusion (MCAO) reduces infarct volume.
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热门标签:Nona-L-arginine TFA