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Berberine

CAS No. : 2086-83-1

MCE 站：Berberine

产品活性：Berberine (Natural Yellow 18) 是从中草药黄连中分离出来的一种生物碱，常用作抗生素。Berberine (Natural Yellow 18) 诱导活性氧 (ROS) 生成并抑制 DNA 拓扑异构酶 (topoisomerase)。Berberine (Natural Yellow 18) 具有抗肿瘤特性。

研究领域：Cell Cycle/DNA Damage  |  Autophagy  |  Anti-infection  |  NF-κB  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation

作用靶点：Topoisomerase  |  Autophagy  |  Bacterial  |  Reactive Oxygen Species  |  Endogenous Metabolite  |  Antibiotic

In Vitro: Berberine (1.25-160 μM; 72 hours) has potential inhibitory effects on the proliferation of four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29.
Berberine (1.25-160 μM; 24-72 hours) induces a time- and dose-dependent inhibition of LoVo cell growth.
LoVo cells are exposure to Berberine (10-80 μM) for 24 h. Cell cycle analysis of 40 μM Berberine-treated LoVo cells by flow cytometry shows accumulation of cells in the G2/M phase.
Berberine (10-80 μM) suppresses cyclin B1, cdc2 and cdc25c protein expression after 24 h, especially at the dose of 80.0 μM.

In Vivo: Berberine (10, 30, or 50 mg/kg/day; gastrointestinal gavage; for 10 consecutive days) inhibits the growth of human colorectal adenocarcinoma in vivo. Berberine at doses of 30 and 50 mg/kg/day taken by gastrointestinal gavage shows inhibitory rates of 33.1% and 45.3% on the human colorectal adenocarcinoma xenograft growth in nude mice.

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