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Abscisic acid

CAS No. : 21293-29-8

MCE 站：Abscisic acid

产品活性：Abscisic acid ((S)-(+)-Abscisic acid) 是一种口服有效的植物激素，存在于水果和蔬菜中，也是一种内源性的哺乳动物激素。Abscisic acid 是一种生长抑制剂，可以调节植物生长发育。Abscisic acid 抑制质子泵 (H⁺-ATPase)，并导致 Ca²⁺ 依赖性的质膜去极化。Abscisic acid 是 LANCL2 的天然配体，是一种有效的胰岛素敏感化合物，具有用于糖尿病前期，2 型糖尿病和代谢综合征研究的潜力。

研究领域：Metabolic Enzyme/Protease  |  Membrane Transporter/Ion Channel

作用靶点：Endogenous Metabolite  |  Proton Pump

In Vitro: In Arabidopsis cell cultures, Abscisic acid ((S)-(+)-Abscisic acid; 10 μM) simultaneously induces rapid alkalinization of the medium and plasma membrane depolarization.
Abscisic acid (10 μM) increases Ca²⁺ in cytosol of Arabidopsis cell suspension. Abscisic acid does not inhibit proton pumping directly but through an increase in cytosolic Ca²⁺.
Lanthionine synthetase C-like 2 (LANCL2) is the natural receptor for Abscisic acid. Abscisic acid, both at the organism levels and in specific muscle cells ex vivo, increases both glucose and fatty acid metabolism in the mitochondria, increases glycogen synthesis, activates PI3K independently of insulin and promotes GLUT4 translocation to the cell membrane.

In Vivo: Abscisic acid (orally; 0.125??g/kg/day; for 12 weeks) improves glycemic control.
Abscisic acid (orally; 0.125??g/kg/day; for 12 weeks) results in significantly lower levels of TNF, MCP-1 and IL-6 in the DIO model. Abscisic acid increases metabolic activity in skeletal muscle.

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