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Choline bitartrate

CAS No. : 87-67-2

MCE 站：Choline bitartrate

产品活性：Choline bitartrate 是一种类似维生素的必需营养素 (vitamin-like essential nutrient)，可影响肝脏疾病、动脉粥样硬化和神经系统疾病等疾病。Choline bitartrate 是神经递质乙酰胆碱的前体，在各种代谢过程和脂质代谢中作为甲基供体 (methyl donor)。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mAChR

In Vitro: Choline serves as a precursor component to two major cell membrane components: phosphatidylcholine and sphingomyelin in vitro.
Choline is also a major source for methyl groups via its metabolite, betaine, which participates in S-adenosylmethionine synthesis pathways.

In Vivo: Choline bitartrate (oral gavage; 300 mg/kg vs. 5 g/kg) is administrated. Choline restriction (300 mg/kg) provokes robust ketosis and weight loss in mice, also causes significant hepatic steatosis, inflammation, and cellular injury. when Choline is repleted, moderate ketosis and hepatic fat accumulation can be attenuated.

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