MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Guanfu base G

CAS No. : 78969-72-9

MCE 站：Guanfu base G

产品活性：Guanfu base G 是一种从 Aconitum coreanum 中分离的抗心律失常生物碱。Guanfu base G 以 IC₅₀ 值为 17.9 μM 来抑制 HERG 通道电流。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: The effects of Guanfu base G is investigated in human embryonic kidney 293 (HEK293) cells transiently transfected with HERG complementary DNA using a whole-cell patch clamp technique. Guanfu base G inhibits HERG channel current in concentration-, voltage-, and time-dependent manners. Guanfu base G shifts the activation curve in a negative direction and accelerated channel inactivation but shows no effect on the inactivation curve. Moreover, Guanfu base G also accelerates channel recovery from inactivation.

In Vivo: Guanfu base G (5 mg/kg; intravenous injection; for 5-1200 minutes; rats) treatment in rats after 15 min could be detected the presence of Guanfu base A, about 10% of Guanfu base G in vivo could metabolize to Guanfu base A, which may be related to the metabolic enzymes in the body and its nature-related compounds, however, the substance in the body to eliminate more quickly, could be detected only around 240 min. The pharmacokinetic behavior of Guanfu base G is better in rats, the T_1/2 is 4.16 hours. These results indicate that Guanfu base G has a relatively suitable elimination half-life.

相关产品：Nigericin sodium salt  |  BAPTA-AM  |  Rosuvastatin Calcium  |  SKF-96365 hydrochloride  |  Glibenclamide  |  SCH-23390 hydrochloride  |  Tetrandrine  |  Amiodarone hydrochloride  |  TRAM-34  |  Ifenprodil tartrate  |  Minoxidil  |  Diazoxide  |  20(S)-Ginsenoside Rg3  |  Senicapoc  |  Tannic acid  |  DCPIB  |  Astemizole  |  Ketanserin  |  Quinine  |  E-4031  |  Terfenadine  |  Hydrochlorothiazide  |  GW9508  |  Daurisoline  |  Nicorandil  |  Dofetilide  |  Pinacidil monohydrate  |  ML277  |  Tolbutamide  |  Almitrine mesylate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。