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Pyripyropene A

CAS No. : 147444-03-9

MCE 站：Pyripyropene A

产品活性：Pyripyropene A 是一种高效、选择性的 SOAT2/ACAT2 抑制剂，其 IC₅₀ 值为 0.07 ?M。Pyripyropene A 在体内能减轻高胆固醇血症和动脉粥样硬化。

研究领域：Metabolic Enzyme/Protease

作用靶点：Acyltransferase

In Vitro: Pyripyropene A (0-100 ?M; 72 hours) exhibits anti-proliferative activity against HUVECs, and with an IC₅₀ value of 1.8 ?M.
Pyripyropene A (10 ?M ; 24 hours) inhibits VEGF (20 ng/ml)-induced migration and tubular formation of HUVECs in dose-dependent fashion.
Pyripyropene A do not show growth inhibitory effects against KB3-1, K562 and Neuro2A cells.

In Vivo: Pyripyropene A (10-50 mg/kg per day; p.o; 12 weeks) reduces the levels of plasma cholesterol, very-low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) and hepatic cholesterol content in apolipoprotein E-knockout mice. And Pyripyropene A-treated mice display reduction of atherogenic lesion areas in the aortae and heart.
Pyripyropene A inhibits the hepatic e acyl–coenzyme A:cholesterol acyltransferase 2 (ACAT2) activity in vivo.
Pyripyropene A displays a half-life (t_1/2) of 0.693/λ, where λ represented the terminal slope of the log-linear portion of concentration time profile.

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