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Songorine

CAS No. : 509-24-0

MCE 站：Songorine

产品活性：Songorine 是从乌头属中分离出的一种二萜生物碱。Songorine 是大鼠脑中的 GABAA 受体拮抗剂，具有抗癌，抗心律不齐和抗炎活性。Songorine 有潜力用于上皮性卵巢癌 (EOC) 的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：GABA Receptor

In Vivo: Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorine?inhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax.
Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD₅₀ and ED₅₀ values of 142 mg and 7.3mg, respectively.

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