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Hydroxycitric acid tripotassium hydrate

CAS No. : 6100-05-6

MCE 站：Hydroxycitric acid tripotassium hydrate

产品活性：Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) 是藤黄果的主要活性成分，也是柠檬酸的衍生物。Hydroxycitric acid tripotassium hydrate 可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ，并具有减肥效果。Hydroxycitric acid tripotassium hydrate 有效抑制结石形成并抑制 HIF，具有抗氧化，抗炎和抗肿瘤作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：ATP Citrate Lyase  |  HIF/HIF Prolyl-Hydroxylase

In Vitro: Hydroxycitric acid shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Hydroxycitric acid can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Hydroxycitric acid suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells.
In chicken hepatocytes, Hydroxycitric acid decreases the accumulation of lipid droplets and accelerated energy metabolism. Hydroxycitric acid protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions.

In Vivo: Hydroxycitric acid (100-200 mg/kg) treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Hydroxycitric acid. Hydroxycitric acid attenuates the oxidative stress induced by calcium oxalate crystallization. Hydroxycitric acid has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Hydroxycitric acid alleviates tubular injury and apoptosis caused by calcium oxalate crystals.
The administration of Hydroxycitric acid can suppress body weight gain and fat accumulation in animals.

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