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5,6-Dihydroxyindole

CAS No. : 3131-52-0

MCE 站：5,6-Dihydroxyindole

产品活性：5,6-Dihydroxyindole 是一种黑色素的前体，具有广谱抗菌，抗真菌，抗病毒，抗寄生虫活性。5,6-Dihydroxyindole 具有细胞毒性作用，并且对各种病原体具有强毒性。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Bacterial  |  Fungal  |  Parasite  |  Endogenous Metabolite

In Vitro: 5,6-Dihydroxyindole (1, 10, 20, 50, 100 μM; for 4 hours) dose-dependently decreases OD₄₉₂ values. Pretreatment of Sf9 cells with 1.0 mM 5,6-Dihydroxyindole for 4 hours results in 97% mortality, and LC₅₀ values of 20.3 μM in buffer and 131.8 μM in a culture medium.
Preincubation of a baculovirus stock with 1.25 mM 5,6-Dihydroxyindole for 3 hours near fully disables recombinant protein production. The LC₅₀ for lambda bacteriophage and eggs of the wasp Microplitis demolitor are 5.6 and 111.0 μM, respectively.
5,6-Dihydroxyindole and its spontaneous oxidation products are also active against viruses and parasitic wasps.

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