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D-Kynurenine

CAS No. : 13441-51-5

MCE 站：D-Kynurenine

产品活性：D-kynurenine 是 D-色氨酸的代谢产物，可以用作健尿酸 (KYNA) 和 3-羟基犬尿氨酸 (3-hydroxykynurenine) 的生物前体。D-kynurenine 是 G 蛋白偶联受体 GPR109B 的激动剂，D-kynurenine 是 D-氨基酸氧化酶荧光分析的底物。D-kynurenine 通过激活芳香烃受体 (AHR) 促进上皮细胞向间充质细胞的转化。

研究领域：Immunology/Inflammation  |  Metabolic Enzyme/Protease

作用靶点：Aryl Hydrocarbon Receptor  |  Endogenous Metabolite

In Vitro: D-kynurenine (10, 40, 60, and 100 ?M) positively regulates the metastasis of 95D cells, a lung cancer cell line, which is reduced upon siRNAAhr treatment. Significant enhancement VIM expression was detected in the presence of D-kynurenine (10 and 40 ?M). 10 ?M D-kynurenine markedly attenuates E-cadherin level. 10 ?M D-kynurenine-mediated changes of VIM and E-cadherin are substantially attenuated on siRNAAhr treatment as well. The evidences-10/40 ?M D-kynurenine-induced up-regulation of CYP1A1, 10 ?M D-kynurenine-induced increase of nuclear transfer of Ahr, and 10/40/60/100 ?M D-kynurenine-induced enhancement of DER-luciferase activity-indicated that D-kynurenine Is capable of activating Ahr in fact.

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