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Azadirachtin B

CAS No. : 106500-25-8

MCE 站：Azadirachtin B

产品活性：Azadirachtin B 是从 Azadirachta indica 种子仁中分离的柠檬苦素。Azadirachtin B 增加碱性磷酸酶 (ALP) 活性并刺激成骨细胞分化。Azadirachtin B 对爱泼斯坦-巴尔病毒早期抗原 (EBV-EA) 具有活性。Azadirachtin B 具有杀虫，杀线虫，抗癌，抗炎，抗病毒和成骨特性。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Parasite  |  Phosphatase  |  Influenza Virus

In Vitro: Azadirachtin B (1 pM-100 ?M; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.
Azadirachtin B increases expression of RunX-2 ?2.5 fold at 10 nM concentration, ALP expression ?2.8 fold at 10 nM and 100 pM concentration and OCN expression ?2.5 folds at 10 nM as compared with control.
Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth (Plutella xylostella) with an LD₅₀ of 4.85-1.06 ?g/g body weight, in 92 h.
Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA).

In Vivo: On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity.

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