MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Oxytetracycline

CAS No. : 79-57-2

MCE 站：Oxytetracycline

产品活性：Oxytetracycline 是一种属于四环素类的抗生素。Oxytetracycline 强力抑制革兰氏阴性和革兰氏阳性细菌。Oxytetracycline 是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合。Oxytetracycline 还具有抗 HSV-1 的活性。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Bacterial  |  HSV  |  Endogenous Metabolite  |  Antibiotic

In Vitro: Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.

In Vivo: The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter.
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Antiviral Compound Library  |  Human Endogenous Metabolite Compound Library  |  Drug Repurposing Compound Library  |  Antibacterial Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Antibiotics Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Rapamycin  |  3-Methyladenine  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Puromycin dihydrochloride  |  Cycloheximide  |  Chloroquine  |  Acetylcysteine  |  5-Fluorouracil  |  Staurosporine  |  Dexamethasone  |  2-Deoxy-D-glucose  |  Doxycycline (hyclate)  |  Actinomycin D  |  Cyclosporin A  |  ATP  |  G-418 disulfate  |  5-Azacytidine  |  Etoposide  |  Mitomycin C  |  CCCP  |  Retinoic acid  |  Nigericin sodium salt  |  Hydrocortisone  |  Brefeldin A  |  Wortmannin  |  Docetaxel  |  Resveratrol  |  Estradiol

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。