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Orotic acid

CAS No. : 65-86-1

MCE 站：Orotic acid

产品活性：Orotic acid (6-Carboxyuracil)，一种嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放，通过细胞质 UMP 合酶转化为 UMP。Orotic acid 是尿素循环异常的常规新生儿筛查中的测量指标。Orotic acid 可引起大鼠肝脂肪变性和肝肿大。

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease

作用靶点：Nucleoside Antimetabolite/Analog  |  Endogenous Metabolite

In Vitro: Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes.

In Vivo: Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD).
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3.

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