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Phenylephrine hydrochloride

CAS No. : 61-76-7

MCE 站：Phenylephrine hydrochloride

产品活性：(R)-(-)-Phenylephrine hydrochloride是一种选择性的α₁-肾上腺素能受体激动剂，对α_1D，α_1B 和α_1A 受体的pK_is 分为5.86，4.87和4.70。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：Adrenergic Receptor  |  Endogenous Metabolite

In Vitro: (R)-(-)-Phenylephrine is a selective α₁-adrenoceptor agonist with pK_i values of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(²⁺)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis.

In Vivo: Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α₁-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema.

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