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Cysteamine hydrochloride

CAS No. : 156-57-0

MCE 站：Cysteamine hydrochloride

产品活性：Cysteamine hydrochloride (β-Mercaptoethylamine Hydrochloride) 是一种可口服的，用于肾病型胱胺酸症得小分子药物，也可作为抗氧化剂。

研究领域：Autophagy  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB  |  Apoptosis

作用靶点：Autophagy  |  Reactive Oxygen Species  |  Apoptosis  |  Endogenous Metabolite

In Vitro: Cysteamine hydrochloride (β-Mercaptoethylamine Hydrochloride) has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine hydrochloride administration. Cysteamine hydrochloride has antioxidant properties as a result of increasing glutathione production. Cysteamine hydrochloride is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine hydrochloride increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine hydrochloride exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine hydrochloride treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine hydrochloride to doxorubicin results in a dramatic increase in cell death.
Cysteamine hydrochloride (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes.

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